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IL23 Protéine

IL23 Origine: Humain Hôte: Insect cells (Sf9) Recombinant > 95 % , as determined by Coomassie stained SDS-PAGE. AbP, Func, PI, STD Active
N° du produit ABIN5505699
  • Antigène Voir toutes IL23 Protéines
    IL23 (Interleukin 23 (IL23))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 6
    • 5
    • 1
    Humain
    Source
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Insect cells (Sf9)
    Application
    Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
    Fonction
    Purified recombinant protein of Human interleukin 23 (p19+p40).
    Specificité
    Optimal preservation of protein structure, post-translational modifications and functions.
    Attributs du produit
    Human IL-23 consists of two subunits linked via a disulfide bond: P19, the region of Ala21- Pro189) from Accession# NP_057668, and P40, the region of Ile 23-Ser 328) from Accession# NP_002178.2
    Pureté
    > 95 % , as determined by Coomassie stained SDS-PAGE.
    niveau d'endotoxine
    Less than 0.01 ng per μg protein as determined by the LAL method.
    Biological Activity Comment
    The ED50 is 0.4 - 2.0 ng/ml, corresponding to a specific activity of 0.5 - 2.50 x 10^6 units/mg determined by mouse splenocyte IL-17A secretion, which is induced by hIL-23 in a dose dependent manner.
    Top Product
    Discover our top product IL23 Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Restrictions
    For Research Use only
  • Concentration
    > 50 μg/mL
    Buffer
    1 x PBS
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    IL23 (Interleukin 23 (IL23))
    Autre désignation
    IL23 (IL23 Produits)
    Synonymes
    IL-23 Protein, p19 Protein, SGRF Protein, il23p19 Protein, interleukin 23, alpha subunit p19 Protein, interleukin 23 subunit alpha Protein, Il23a Protein, IL23A Protein
    Sujet
    This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
    Poids moléculaire
    53.3 kDa
    NCBI Accession
    NP_057668
    UniProt
    Q9NPF7
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