Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

IDO1 Protein (AA 1-403) (His tag)

IDO1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant >90 % (SDS-PAGE) SDS Active
N° du produit ABIN5564386
  • Antigène Voir toutes IDO1 Protéines
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 1-403
    Origine
    • 9
    • 4
    • 1
    Humain
    Source
    • 7
    • 2
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette IDO1 protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
     Réactivité croisée
    Humain
    Attributs du produit
    Human IDO (aa 1-403) is fused at the N-terminus to a His-tag.
    Pureté
    >90 % (SDS-PAGE)
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IDO1 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Specific Activity: >100'000U/mg protein with L-tryptophan as substrate (activity assay with catalase). One unit is defined as the amount of enzyme that produces 1nmol of N-formylkynurenine (NFK) per hour. For more information see Activity Test Protocol.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    0.2μm-filtered solution in 10 mM Tris, pH 7.5, containing 100 mM NaCl and 20 % glycerol.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Short Term Storage: -20°C
    Long Term Storage: -80°C
    Stable for at least 1 year after receipt when stored at -80°C.
    Date de péremption
    12 months
  • Antigène
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Autre désignation
    IDO (IDO1 Produits)
    Synonymes
    INDO Protein, ido Protein, indo Protein, IDO Protein, cd107b Protein, IDO1 Protein, IDO-1 Protein, Ido Protein, Indo Protein, indoleamine 2,3-dioxygenase 1 Protein, indoleamine 2,3-dioxygenase 1 L homeolog Protein, indoleamine 2,3-dioxygenase 1-like Protein, IDO1 Protein, ido1.L Protein, ido1 Protein, Ido1 Protein, LOC100050681 Protein
    Sujet
    IDO is a heme enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO is an immune checkpoint protein, thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. Cancer cells are able to evade the immune system is by hijacking the checkpoint proteins. Increased IDO protein levels drive growth arrest and apoptosis of the effector T cells, a group of immune cells that mediate the immune system's ability to destroy pathogens. By reducing the number of effector T cells, IDO overexpression prevents the immune system from effectively destroying cancer cells. IDO overexpression has been observed in a wide range of human cancers such as prostatic, colorectal, pancreatic, cervical, gastric, ovarian, head or lung cancer. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders. Biological active IDO enzyme can be used for screening of IDO inhibitors, which have shown promising antitumor activity and appear to be synergistic in combination with chemotherapy and other forms of immunotherapy.
    Poids moléculaire
    ~47kDa (SDS-PAGE)
    UniProt
    P14902
    Pathways
    Activated T Cell Proliferation
Vous êtes ici:
Support technique