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BRCC3 Protein (AA 2-316) (His-SUMO Tag)

BRCC3 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % SDS
N° du produit ABIN5709149
  • Antigène Voir toutes BRCC3 Protéines
    BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 2-316
    Origine
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 6
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette BRCC3 protéine est marqué à la His-SUMO Tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    AVQVVQAVQA VHLESDAFLV CLNHALSTEK EEVMGLCIGE LNDDTRSDSK FAYTGTEMRT VAEKVDAVRI VHIHSVIILR RSDKRKDRVE ISPEQLSAAS TEAERLAELT GRPMRVVGWY HSHPHITVWP SHVDVRTQAM YQMMDQGFVG LIFSCFIEDK NTKTGRVLYT CFQSIQAQKS SESLHGPRDF WSSSQHISIE GQKEEERYER IEIPIHIVPH VTIGKVCLES AVELPKILCQ EEQDAYRRIH SLTHLDSVTK IHNGSVFTKN LCSQMSAVSG PLLQWLEDRL EQNQQHLQEL QQEKEELMQE LSSLE
    Purification
    SDS-PAGE
    Pureté
    > 90 %
    Top Product
    Discover our top product BRCC3 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Stock
    -80 °C,4 °C,-20 °C
    Stockage commentaire
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Antigène
    BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
    Autre désignation
    BRCC3 (BRCC3 Produits)
    Synonymes
    CXorf53 Protein, BRCC3 Protein, xtp1 Protein, brcc3 Protein, BRCC36 Protein, brcc36 Protein, C6.1A Protein, BRCA1/BRCA2-containing complex subunit 3 Protein, DEP domain containing 1B Protein, BRCA1/BRCA2-containing complex, subunit 3 Protein, BRCA1/BRCA2-containing complex subunit 3 L homeolog Protein, BRCC3 Protein, depdc1b Protein, brcc3 Protein, Brcc3 Protein, brcc3.L Protein
    Sujet
    Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically roves 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex
    Poids moléculaire
    51.9 kDa
    UniProt
    P46736
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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