POLR3K Protein (AA 1-108, full length) (His-SUMO Tag)

N° du produit ABIN5710125

Détail du produit

Antigène: POLR3K (Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-108

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette POLR3K protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: MLLFCPGCGN GLIVEEGQRC HRFACNTCPY VHNITRKVTN RKYPKLKEVD DVLGGAAAWE NVDSTAESCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA QCGHRWRD

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: POLR3K (Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K))

Autre désignation: RPC10 (POLR3K Produits)

Synonymes: MGC108467 Protein, POLR3K Protein, 12.3kDa Protein, 1500004O14Rik Protein, AI196849 Protein, AU014893 Protein, C11 Protein, RPC10 Protein, RPC11 Protein, C11-RNP3 Protein, RPC12.5 Protein, hRPC11 Protein, RNA polymerase III subunit K Protein, polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa S homeolog Protein, polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa Protein, polymerase (RNA) III (DNA directed) polypeptide K Protein, Polr3k Protein, polr3k.S Protein, polr3k Protein, POLR3K Protein

Sujet: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway .

Poids moléculaire: 28.3 kDa

UniProt: Q9Y2Y1