STAT3 Protein (AA 50-240, partial) (His-SUMO Tag)

N° du produit ABIN5710422

Détail du produit

Antigène: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Type de proteíne: Recombinant

Attributs du protein: AA 50-240, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette STAT3 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: ESHATLVFHN LLGEIDQQYS RFLQESNVLY QHNLRRIKQF LQSRYLEKPM EIARIVARCL WEESRLLQTA ATAAQQGGQA NHPTAAVVTE KQQMLEQHLQ DVRKRVQDLE QKMKVVENLQ DDFDFNYKTL KSQGDMQDLN GNNQSVTRQK MQQLEQMLTA LDQMRRSIVS ELAGLLSAME YVQKTLTDEE L

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Autre désignation: STAT3 (STAT3 Produits)

Synonymes: 1110034C02Rik Protein, AW109958 Protein, Aprf Protein, APRF Protein, HIES Protein, Xstat3 Protein, aprf Protein, hies Protein, stat3 Protein, wu:fc15d02 Protein, wu:fl59g06 Protein, z-Stat3 Protein, signal transducer and activator of transcription 3 Protein, signal transduction and activation of transcription 3 Protein, signal transducer and activator of transcription 3, gene 1 L homeolog Protein, signal transducer and activator of transcription 3 (acute-phase response factor) Protein, STAT3 Protein, stat3 Protein, Stat3 Protein, stat3.1.L Protein

Sujet: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elents identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G .

Poids moléculaire: 38.2 kDa

UniProt: P40763

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor