TRIM24 Protein (AA 891-1012, partial) (His-SUMO Tag)

N° du produit ABIN5710552

Détail du produit

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Type de proteíne: Recombinant

Attributs du protein: AA 891-1012, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette TRIM24 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: KKKTEGLVKL TPIDKRKCER LLLFLYCHEM SLAFQDPVPL TVPDYYKIIK NPMDLSTIKK RLQEDYSMYS KPEDFVADFR LIFQNCAEFN EPDSEVANAG IKLENYFEEL LKNLYPEKRF PK

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Autre désignation: TIF1A (TRIM24 Produits)

Synonymes: TRIM24 Protein, PTC6 Protein, RNF82 Protein, TF1A Protein, TIF1 Protein, TIF1A Protein, TIF1ALPHA Protein, hTIF1 Protein, ptc6 Protein, rnf82 Protein, tf1a Protein, tif1 Protein, tif1a Protein, tif1alpha Protein, A130082H20Rik Protein, AI447469 Protein, D430004I05Rik Protein, TIF1-alpha Protein, TIF1alpha Protein, Tif1a Protein, tripartite motif containing 24 Protein, transcription intermediary factor 1-alpha Protein, tripartite motif containing 24 S homeolog Protein, tripartite motif-containing 24 Protein, TRIM24 Protein, trim24 Protein, LOC100548578 Protein, trim24.S Protein, Trim24 Protein

Sujet: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes .

Poids moléculaire: 30.47 kDa

UniProt: O15164