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FHIT Protein (AA 2-150) (His tag)

FHIT Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 90 % SDS
N° du produit ABIN5711223
  • Antigène Voir toutes FHIT Protéines
    FHIT (Fragile Histidine Triad (FHIT))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 2-150
    Origine
    • 4
    • 2
    • 1
    • 1
    • 1
    Souris
    Source
    • 4
    • 3
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette FHIT protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    SFRFGQHLIK PSVVFLKTEL SFALVNRKPV VPGHVLVCPL RPVERFRDLH PDEVADLFQV TQRVGTVVEK HFQGTSITFS MQDGPEAGQT VKHVHVHVLP RKAGDFPRND NIYDELQKHD REEEDSPAFW RSEKEMAAEA EALRVYFQA
    Purification
    SDS-PAGE
    Pureté
    > 90 %
    Top Product
    Discover our top product FHIT Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Stock
    -80 °C,4 °C,-20 °C
    Stockage commentaire
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Antigène
    FHIT (Fragile Histidine Triad (FHIT))
    Autre désignation
    FHIT (FHIT Produits)
    Synonymes
    AP3Aase Protein, FRA3B Protein, FHIT Protein, zgc:73176 Protein, AW045638 Protein, Fra14A2 Protein, LOC100223655 Protein, fragile histidine triad Protein, fragile histidine triad gene Protein, fragile histidine triad protein Protein, fragile histidine triad L homeolog Protein, FHIT Protein, Fhit Protein, fhit Protein, PY07476 Protein, fhit.L Protein
    Sujet
    Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extrely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity . Functions as tumor suppressor.
    Poids moléculaire
    21.2 kDa
    UniProt
    O89106
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