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Sorting Nexin 1 Protein (SNX1) (AA 1-522, full length) (His-SUMO Tag)

SNX1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % SDS
N° du produit ABIN5711327
  • Antigène Voir toutes Sorting Nexin 1 (SNX1) Protéines
    Sorting Nexin 1 (SNX1)
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-522, full length
    Origine
    • 5
    • 1
    • 1
    • 1
    Humain
    Source
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette Sorting Nexin 1 protéine est marqué à la His-SUMO Tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    MASGGGGCSA SERLPPPFPG LEPESEGAAG GSEPEAGDSD TEGEDIFTGA AVVSKHQSPK ITTSLLPINN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVLA KTLISLPPQE ATNSSKPQPT YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPLFRSKQ FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW QDAQATLQKK REAEARLLWA NKPDKLQQAK DEILEWESRV TQYERDFERI STVVRKEVIR FEKEKSKDFK NHVIKYLETL LYSQQQLAKY WEAFLPEAKA IS
    Purification
    SDS-PAGE
    Pureté
    > 90 %
    Top Product
    Discover our top product SNX1 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Stock
    -80 °C,4 °C,-20 °C
    Stockage commentaire
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Antigène
    Sorting Nexin 1 (SNX1)
    Autre désignation
    SNX1 (SNX1 Produits)
    Synonymes
    d254 Protein, sb:cb923 Protein, snx1 Protein, wu:fb40c08 Protein, wu:fj65g09 Protein, MGC82200 Protein, SNX1 Protein, HsT17379 Protein, VPS5 Protein, ARABIDOPSIS THALIANA SORTING NEXIN 1 Protein, ATSNX1 Protein, K16F4.11 Protein, K16F4_11 Protein, sorting nexin 1 Protein, sorting nexin 1a Protein, sorting nexin 1 L homeolog Protein, sorting nexin 1 Protein, sorting nexin-1 Protein, snx1a Protein, snx1.L Protein, SNX1 Protein, snx1 Protein, LOC100380673 Protein, Snx1 Protein
    Sujet
    Involved in several stages of intracellular trafficking. Interacts with mbranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Acts in part as component of the retromer mbrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma mbrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor mbrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense mbrane curvature and has in vitro vesicle-to-mbrane rodeling activity . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi . Involvent in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R . Promotes KALRN- and RHOG-dependent but retromer-independent mbrane rodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN . Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking .
    Poids moléculaire
    75.07 kDa
    UniProt
    Q13596
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