CHCHD4 Protein (AA 1-142, full length) (His-SUMO Tag)

N° du produit ABIN5711676

Détail du produit

Antigène: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-142

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CHCHD4 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: MSYCRQEGKD RIIFVTKEDH ETPSSAELVA DDPNDPYEEH GLILPNGNIN WNCPCLGGMA SGPCGEQFKS AFSCFHYSTE EIKGSDCVDQ FRAMQECMQK YPDLYPQEDE DEEEEREKKP AEQAEETAPI EATATKEEEG SS

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Autre désignation: MIA40 (CHCHD4 Produits)

Synonymes: 2410012P20Rik Protein, 2810014D17Rik Protein, AI838740 Protein, MIA40 Protein, TIMM40 Protein, mia40 Protein, timm40 Protein, chchd4 Protein, chchd4a Protein, fc10g04 Protein, wu:fc10g04 Protein, zgc:100849 Protein, si:dkey-202e22.1 Protein, chchd4b Protein, CaO19.2977 Protein, coiled-coil-helix-coiled-coil-helix domain containing 4 Protein, coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog Protein, coiled-coil-helix-coiled-coil-helix domain containing 4a Protein, coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog Protein, Mia40p Protein, Chchd4 Protein, CHCHD4 Protein, chchd4 Protein, chchd4.L Protein, chchd4a Protein, chchd4.S Protein, LOC100361898 Protein, MIA40 Protein

Sujet: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermbrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay syst.

Poids moléculaire: 32 kDa

UniProt: Q8N4Q1