MYLIP Protein (AA 1-445, full length) (GST tag)

N° du produit ABIN5711701

Détail du produit

Antigène: MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-445

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MYLIP protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS)

Séquence: MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV CRSRVEHVQH VYLPTHTSLL NLTVI

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))

Autre désignation: MYLIP (MYLIP Produits)

Synonymes: IDOL Protein, MIR Protein, 9430057C20Rik Protein, Mir Protein, mylip Protein, wu:fj36b03 Protein, zgc:55987 Protein, MYLIP Protein, mir Protein, zgc:153767 Protein, myosin regulatory light chain interacting protein Protein, myosin regulatory light chain interacting protein a Protein, myosin regulatory light chain interacting protein L homeolog Protein, myosin regulatory light chain interacting protein b Protein, MYLIP Protein, Mylip Protein, mylipa Protein, mylip.L Protein, mylip Protein, mylipb Protein

Sujet: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Poids moléculaire: 77.3 kDa

UniProt: Q8WY64