GEMIN7 Protein (AA 1-131, full length) (GST tag)

N° du produit ABIN5711759

Détail du produit

Antigène: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-131

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GEMIN7 protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS)

Séquence: MQTPVNIPVP VLRLPRGPDG FSRGFAPDGR RAPLRPEVPE IQECPIAQES LESQEQRARA ALRERYLRSL LAMVGHQVSF TLHEGVRVAA HFGATDLDVA NFYVSQLQTP IGVQAEALLR CSDIISYTFK P

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Autre désignation: GEMI7 (GEMIN7 Produits)

Synonymes: SIP3 Protein, GEMIN7 Protein, Gemin7 Protein, 2400008I04Rik Protein, AI120175 Protein, AI461688 Protein, gem nuclear organelle associated protein 7 Protein, gem (nuclear organelle) associated protein 7 Protein, GEMIN7 Protein, Gemin7 Protein

Sujet: The SMN complex plays a catalyst role in the assbly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assbly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assbly of core snRNPs and their transport to the nucleus.

Poids moléculaire: 41.9 kDa

UniProt: Q9H840

Pathways: Ribonucleoprotein Complex Subunit Organization