MCTS1 Protein (AA 1-181, full length) (His-SUMO Tag)

N° du produit ABIN5711965

Détail du produit

Antigène: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-181

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MCTS1 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV KIVRCHEHIE ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG AKLYPAAVDT IVAIMAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY K

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Autre désignation: MCTS1 (MCTS1 Produits)

Synonymes: MCT-1 Protein, MCT1 Protein, MCT1a Protein, cb517 Protein, zgc:55682 Protein, 1500019M23Rik Protein, zgc:56242 Protein, mcts1 Protein, MGC89874 Protein, MCTS1 Protein, MCT-1A Protein, mct-1 Protein, mct1 Protein, MCT-1B Protein, mcts1-a Protein, mcts1-b Protein, MCTS1, re-initiation and release factor Protein, solute carrier family 16 (monocarboxylate transporter), member 1b Protein, malignant T cell amplified sequence 1 Protein, malignant T-cell amplified sequence 1 Protein, solute carrier family 16 member 1 Protein, malignant T-cell amplified sequence 1 S homeolog Protein, monocarboxylate transporter 1 Protein, malignant T-cell amplified sequence 1 L homeolog Protein, MCTS1 Protein, slc16a1b Protein, Mcts1 Protein, mcts1 Protein, SLC16A1 Protein, mcts1.S Protein, MCT1 Protein, mcts1.L Protein

Sujet: Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels rains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits

Poids moléculaire: 36.54 kDa

UniProt: Q9ULC4