UFD1L Protein (AA 1-307) (His tag)

N° du produit ABIN5853130

Détail du produit

Antigène: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Type de proteíne: Recombinant

Attributs du protein: AA 1-307

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette UFD1L protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMFSFNMF DHPIPRVFQN RFSTQYRCFS VSMLAGPNDR SDVEKGGKII MPPSALDQLS RLNITYPMLF KLTNKNSDRM THCGVLEFVA DEGICYLPHW MMQNLLLEEG GLVQVESVNL QVATYSKFQP QSPDFLDITN PKAVLENALR NFACLTTGDV IAINYNEKIY ELRVMETKPD KAVSIIECDM NVDFDAPLGY KEPERQVQHE ESTEGEADHS GYAGELGFRA FSGSGNRLDG KKKGVEPSPS PIKPGDIKRG IPNYEFKLGK ITFIRNSRPL VKKVEEDEAG GRFVAFSGEG QSLRKKGRKP

Pureté: > 85 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.1M NaCl, 30 % glycerol, 1  mM DTT

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Autre désignation: uFD1L (UFD1L Produits)

Synonymes: UFD1 Protein, Ufd1 Protein, ufd1 Protein, wu:fc55f04 Protein, zgc:92341 Protein, Ufd1l Protein, ubiquitin recognition factor in ER associated degradation 1 Protein, ubiquitin recognition factor in ER-associated degradation 1 Protein, ubiquitin fusion degradation 1 like (yeast) Protein, ubiquitin recognition factor in ER associated degradation 1 S homeolog Protein, ubiquitin fusion degradation protein 1 homolog Protein, Ubiquitin Fusion Degradation (yeast UFD homolog) Protein, UFD1 Protein, Ufd1 Protein, UFD1L Protein, ufd1.S Protein, ufd1l Protein, ufd1 Protein, EHI_125920 Protein, LOC100166745 Protein, LOC100635687 Protein, LOC100648660 Protein, ufd-1 Protein

Sujet: UFD1L forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. Recombinant human uFD1L protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 36.9 kDa (330aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)

NCBI Accession: NP_005650

UniProt: Q92890