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Norrie Disease (Pseudoglioma) Protein (NDP) (AA 25-133) (His tag)

NDP Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 80 % by SDS - PAGE SDS
N° du produit ABIN5853193
  • Antigène Voir toutes Norrie Disease (Pseudoglioma) (NDP) Protéines
    Norrie Disease (Pseudoglioma) (NDP)
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 25-133
    Origine
    • 3
    • 1
    • 1
    • 1
    Humain
    Source
    • 2
    • 2
    • 2
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette Norrie Disease (Pseudoglioma) protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS
    Pureté
    > 80 % by SDS - PAGE
    Top Product
    Discover our top product NDP Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Denatured

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Antigène
    Norrie Disease (Pseudoglioma) (NDP)
    Autre désignation
    NDP (NDP Produits)
    Synonymes
    EVR2 Protein, FEVR Protein, ND Protein, evr2 Protein, fevr Protein, xnorrin Protein, Ndph Protein, RGD1563968 Protein, NDP, norrin cystine knot growth factor Protein, Norrie disease (pseudoglioma) L homeolog Protein, Norrie disease (pseudoglioma) (human) Protein, NDP Protein, ndp.L Protein, Ndp Protein
    Sujet
    Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli.
    Poids moléculaire
    14.8 kDa (132aa)
    NCBI Accession
    NP_000257
    UniProt
    Q00604
    Pathways
    Sensory Perception of Sound
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