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TRIAP1 Protein (AA 1-76) (His tag)
TRIAP1
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 90 % by SDS - PAGE
SDS
N° du produit ABIN5853375
Détail du produit
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Antigène
Voir toutes TRIAP1 Protéines
TRIAP1
(TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1))
Type de proteíne
Recombinant
Attributs du protein
AA 1-76
Origine
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Humain
Source
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Escherichia coli (E. coli)
Purification/Conjugué
Cette TRIAP1 protéine est marqué à la His tag.
Application
SDS-PAGE (SDS)
Séquence
MGSSHHHHHH SSGLVPRGSH MGSMNSVGEA CTDMKREYDQ CFNRWFAEKF LKGDSSGDPC TDLFKRYQQC VQKAIKEKEI PIEGLEFMGH GKEKPENSS
Pureté
> 90 % by SDS - PAGE
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Alternatives
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.1M NaCl, 20 % glycerol, 1 mM DTT
Stock
4 °C,-20 °C,-80 °C
Stockage commentaire
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Détail du antigène
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Antigène
TRIAP1
(TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1))
Autre désignation
TRIAP1 (TRIAP1 Produits )
Synonymes
MDM35 Protein, P53CSV Protein, WF-1 Protein, 1810015M01Rik Protein, AU020874 Protein, AU043831 Protein, P53csv Protein, Wf-1 Protein, p53csv-A Protein, triap1 Protein, triap1a Protein, p53csv-B Protein, triap1-a Protein, triap1-b Protein, triap1b Protein, zgc:112025 Protein, TP53 regulated inhibitor of apoptosis 1 Protein, TP53 regulated inhibitor of apoptosis 1 S homeolog Protein, TP53 regulated inhibitor of apoptosis 1 L homeolog Protein, TRIAP1 Protein, Triap1 Protein, triap1.S Protein, triap1.L Protein, triap1 Protein
Sujet
TP53-regulated inhibitor of apoptosis 1, also known as TRIAP1, contains a p53-binding site within its second exon and the reduction of expression by small interfering RNA enhanced apoptosis, whereas overexpression protected cells from apoptosis caused by DNA damage. TRIAP1 is induced significantly when cells have a low level of genotoxic stresses, but not when DNA damage is severe. TRIAP1 can modulate apoptotic pathways through interaction with Hsp70 that probably inhibits activity of apoptosis protease activating factor-1. Recombinant human TRIAP1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Poids moléculaire
11.2kDa (99aa), confirmed by MALDI-TOF
NCBI Accession
NP_057483
UniProt
O43715
Pathways
Negative Regulation of intrinsic apoptotic Signaling
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