ARPP19 Protein (AA 1-112) (His tag)

N° du produit ABIN5853398

Détail du produit

Antigène: ARPP19 (cAMP-Regulated Phosphoprotein, 19kDa (ARPP19))

Type de proteíne: Recombinant

Attributs du protein: AA 1-112

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ARPP19 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMSAEVPE AASAEEQKEM EDKVTSPEKA EEAKLKARYP HLGQKPGGSD FLRKRLQKGQ KYFDSGDYNM AKAKMKNKQL PTAAPDKTEV TGDHIPTPQD LPQRKPSLVA SKLAG

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: ARPP19 (cAMP-Regulated Phosphoprotein, 19kDa (ARPP19))

Autre désignation: ARPP19 (ARPP19 Produits)

Synonymes: ARPP-16 Protein, ARPP-19 Protein, ARPP16 Protein, ENSAL Protein, ARPP-19-A Protein, arpp-16 Protein, arpp-19 Protein, arpp16 Protein, arpp19-a Protein, ensal Protein, 19kDa Protein, 2700024H10Rik Protein, AW559096 Protein, Arpp12 Protein, Arpp19 Protein, Arpp-19 Protein, cAMP regulated phosphoprotein 19 Protein, cAMP regulated phosphoprotein 19kDa L homeolog Protein, cAMP-regulated phosphoprotein 19 Protein, ARPP19 Protein, arpp19.L Protein, Arpp19 Protein

Sujet: CAMP-regulated phosphoprotein 19, also known as ARPP19, is protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. This protein may indirectly enhance GAP-43 expression. Recombinant human ARPP19 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 14.7kDa (135aa) confirmed by MALDI-TOF

NCBI Accession: NP_006619

UniProt: P56211

Pathways: Regulation of Carbohydrate Metabolic Process