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Parkin Protein (AA 1-465) (His tag)

PARK2 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 80 % by SDS - PAGE SDS
N° du produit ABIN5853490
  • Antigène Voir toutes Parkin (PARK2) Protéines
    Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-465
    Origine
    • 7
    • 1
    • 1
    Humain
    Source
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette Parkin protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    MGSSHHHHHH SSGLVPRGSH MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV
    Pureté
    > 80 % by SDS - PAGE
    Top Product
    Discover our top product PARK2 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Denatured

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Antigène
    Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
    Autre désignation
    PARK2 (PARK2 Produits)
    Synonymes
    CG10523 Protein, Dmel\\CG10523 Protein, Dpark Protein, SD01679 Protein, dpk Protein, AR-JP Protein, LPRS2 Protein, PDJ Protein, PRKN Protein, Park Protein, Prkn Protein, si:ch211-123f21.1 Protein, zgc:112390 Protein, pdr-1 Protein, PARK2 Protein, parkin Protein, parkin RBR E3 ubiquitin protein ligase Protein, Parkinson disease (autosomal recessive, juvenile) 2, parkin Protein, park Protein, PRKN Protein, Prkn Protein, prkn Protein, CpipJ_CPIJ014867 Protein, Park2 Protein
    Sujet
    The precise function of this gene is unknown, however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. Recombinant human PARK2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
    Poids moléculaire
    53.8 kDa (485aa)
    NCBI Accession
    NP_004553
    UniProt
    O60260
    Pathways
    Autophagy, Ubiquitin Proteasome Pathway
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