Epigen Protein (AA 23-110) (His tag)

N° du produit ABIN5855016

Détail du produit

Antigène: Epigen (EPGN) (Epithelial Mitogen (EPGN))

Type de proteíne: Recombinant

Attributs du protein: AA 23-110

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette Epigen protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: ADPAAVTVTP PITAQQGNWT VNKTEADNIE GPIALKFSHL CLEDHNSYCI NGACAFHHEL EKAICRCFTG YTGERCEHLT LTSYAVDSYE KHHHHHH

Pureté: > 90 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: Epigen (EPGN) (Epithelial Mitogen (EPGN))

Autre désignation: EPGN (EPGN Produits)

Synonymes: ALGV3072 Protein, EPG Protein, PRO9904 Protein, 2310069M11Rik Protein, epigen Protein, RGD1560084 Protein, epithelial mitogen Protein, EPGN Protein, Epgn Protein

Sujet: EPGN, also known as epigen isoform 1, is a novel member of the epidermal growth factor superfamily. It is the last ligand of ErbB receptors and reveals intricate relationships between affinity and mitogenicity. It stimulated the proliferation of HaCaT cells, and this proliferation was blocked by an antibody to the extracellular domain of the receptor tyrosine kinase c-erbB-1. It also may constitute a novel molecular target for wound-healing therapy with its ability to promote the growth of epithelial cells. It has been reported to have high mitogenic activity but low affinity for its receptor. It has been reported in cancer specimens of the breast, bladder, and prostate. Recombinant human EPGN, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 10.8kDa (97aa) 13.5-18kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_001257918

UniProt: Q6UW88

Pathways: Signalisation RTK, EGFR Signaling Pathway