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IL1A Protein (AA 113-271) (His tag)

IL1A Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant >98 % (SDS-PAGE)
N° du produit ABIN7278696
  • Antigène Voir toutes IL1A Protéines
    IL1A (Interleukin 1 alpha (IL1A))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 113-271
    Origine
    • 17
    • 13
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Source
    • 39
    • 13
    • 12
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette IL1A protéine est marqué à la His tag.
    Fonction
    IL-1alpha (human) (rec.) (His)
    Specificité
    Human IL-1alpha (aa 113-271) is fused at the C-terminus to a His-tag.
    Attributs du produit
    Protein. Human IL-1alpha (aa 113-271) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.1EU/μg protein (LAL test, Lonza). Lyophilized from a concentrated sterile solution containing 50  mM Tris-HCl buffer (  pH 8.0) and 100  mM NaCl. Purity: >98 % (SDS-PAGE). The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
    Pureté
    >98 % (SDS-PAGE)
    niveau d'endotoxine
    <0.1EU/μg protein (LAL test, Lonza).
    Top Product
    Discover our top product IL1A Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized from a concentrated sterile solution containing 50  mM Tris-HCl buffer (  pH 8.0) and 100  mM NaCl.
    Conseil sur la manipulation
    Avoid freeze/thaw cycles.
    Stock
    4 °C,-20 °C
    Stockage commentaire

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • Antigène
    IL1A (Interleukin 1 alpha (IL1A))
    Autre désignation
    IL-1alpha (IL1A Produits)
    Synonymes
    IL-1A Protein, IL1 Protein, IL1-ALPHA Protein, IL1F1 Protein, IL-6 Protein, Il-1a Protein, IL-1 alpha Protein, IL-1alpha Protein, L1A Protein, interleukin 1 alpha Protein, interleukin 6 Protein, IL1A Protein, IL6 Protein, Il1a Protein
    Sujet

    Alternate Names/Synonyms: Interleukin-1alpha, IL-1F1, IL-1A

    Product Description: The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

    NCBI Accession
    NP_000566
    Pathways
    Signalisation NF-kappaB, Autophagy, Cancer Immune Checkpoints
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