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IL12 Protein (AA 1-335, AA 23-215) (Fc Tag)

IL12 Origine: Souris Hôte: CHO Cells Recombinant >98 % (SDS-PAGE)
N° du produit ABIN6253330
  • Antigène Voir toutes IL12 Protéines
    IL12 (Interleukin 12 (IL12))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-335, AA 23-215
    Origine
    • 18
    • 9
    • 5
    • 1
    Souris
    Source
    • 14
    • 5
    • 5
    • 3
    • 2
    • 1
    CHO Cells
    Purification/Conjugué
    Cette IL12 protéine est marqué à la Fc Tag.
    Fonction
    IL-12 (mouse):Fc (human) (rec.)
    Specificité
    The mouse IL-12 complex composed of the p40 subunit (aa 1-335) and the p35 subunit (aa 23-215) is fused through a polypeptide linker to the Fc region of human IgG1.
    Attributs du produit
    Protein. The mouse IL-12 complex composed of the p40 subunit (aa 1-335) and the p35 subunit (aa 23-215) is fused through a polypeptide linker to the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells, the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen, and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumor and anti viral agent.
    Pureté
    >98 % (SDS-PAGE)
    niveau d'endotoxine
    <0.06EU/μg protein (LAL test, Lonza).
    Top Product
    Discover our top product IL12 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in PBS.
    Conseil sur la manipulation
    Avoid freeze/thaw cycles.
    Stock
    4 °C,-20 °C
    Stockage commentaire

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • Antigène
    IL12 (Interleukin 12 (IL12))
    Autre désignation
    IL-12 (IL12 Produits)
    Synonymes
    CLMF Protein, CLMF2 Protein, IL-12B Protein, NKSF Protein, NKSF2 Protein, p40 Protein, Il-12b Protein, Il12p40 Protein, Il-12p40 Protein, Il12 Protein, IL-12p40 Protein, IL-12 Protein, LOC100217488 Protein, IL-12p35 Protein, Il-12a Protein, Ll12a Protein, p35 Protein, IL12p40 Protein, IL12B Protein, IL-12 p35 Protein, interleukin 12B Protein, interleukin 12A Protein, interleukin 12b Protein, interleukin 12a Protein, Interleukin 12 level Protein, IL12B Protein, IL12A Protein, Il12b Protein, Il12a Protein, IL12 Protein, il12a Protein
    Sujet

    Alternate Names/Synonyms: IL12-p70, CLMF, Cytotoxic Lymphocyte Maturation Factor, NKSF, Natural Killer Cell Stimulatory Factor, TSF, T cell Stimulating Factor

    Product Description: Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells, the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen, and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumor and anti viral agent.

    NCBI Accession
    NP_032377
    Pathways
    Signalistation JAK/STAT, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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