CCL4 Protein (AA 24-92) (Fc Tag)

N° du produit ABIN7278682

Détail du produit

Antigène: CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))

Type de proteíne: Recombinant

Attributs du protein: AA 24-92

Origine: Humain

Source: CHO Cells

Purification/Conjugué: Cette CCL4 protéine est marqué à la Fc Tag.

Fonction: CCL4 (human):Fc (human) (rec.)

Specificité: The extracellular domain of human CCL4 (aa 24-92) is fused to the N-terminus of the Fc region of human IgG1.

Attributs du produit: Protein. The extracellular domain of human CCL4 (aa 24-92) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CCL4, (C-C motif chemokine 4, macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.

Pureté: >98 % (SDS-PAGE)

niveau d'endotoxine: <0.06EU/μg protein (LAL test, Lonza).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Détail du antigène

Antigène: CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))

Autre désignation: CCL4 (CCL4 Produits)

Synonymes: ACT2 Protein, AT744.1 Protein, G-26 Protein, HC21 Protein, LAG-1 Protein, LAG1 Protein, MIP-1-beta Protein, MIP1B Protein, MIP1B1 Protein, SCYA2 Protein, SCYA4 Protein, CCL4 Protein, K203 Protein, Mip1-b Protein, Scya4 Protein, MIP-1beta Protein, MIP-1BETA Protein, MIP1b Protein, SCY4A Protein, Act-2 Protein, MIP-1B Protein, Mip1b Protein, ACT-2 Protein, AT744.2 Protein, CCL4L Protein, SCYA4L Protein, SCYA4L1 Protein, SCYA4L2 Protein, C-C motif chemokine ligand 4 Protein, chemokine (C-C motif) ligand 4 Protein, chemokine (C-C motif) ligand 4-like 1 Protein, C-C motif chemokine ligand 4 like 1 Protein, CCL4 Protein, Ccl4 Protein, CCL4L1 Protein

Sujet:

Alternate Names/Synonyms: C-C Motif Chemokine 4, Lymphocyte Activation Gene 1 Protein, LAG-1, Macrophage Inflammatory Protein 1beta, MIP-1beta, T Cell Activation Protein 2, ACT-2, Small-inducible Cytokine A4, PAT 744, Protein H400

Product Description: CCL4, (C-C motif chemokine 4, macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.