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ICOS Protein (AA 21-139) (Fc Tag)

ICOS Origine: Humain Hôte: CHO Cells Recombinant >98 % (SDS-PAGE)
N° du produit ABIN7278695
  • Antigène Voir toutes ICOS Protéines
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 21-139
    Origine
    • 17
    • 11
    • 4
    • 1
    • 1
    • 1
    Humain
    Source
    • 16
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    CHO Cells
    Purification/Conjugué
    Cette ICOS protéine est marqué à la Fc Tag.
    Fonction
    CD278 [ICOS] (human):Fc (human) (rec.) (non-lytic)
    Specificité
    The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of a mutant human IgG1.
    Attributs du produit
    Protein. The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
    Pureté
    >98 % (SDS-PAGE)
    niveau d'endotoxine
    <0.06EU/μg protein (LAL test, Lonza).
    Biological Activity Comment
    Shows the biological function of the CD278 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
    Top Product
    Discover our top product ICOS Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in PBS.
    Conseil sur la manipulation
    Avoid freeze/thaw cycles.
    Stock
    4 °C,-20 °C
    Stockage commentaire

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • Antigène
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Autre désignation
    CD278 [ICOS] (ICOS Produits)
    Synonymes
    ICOS Protein, AILIM Protein, CCLP Protein, CRP-1 Protein, H4 Protein, Ly115 Protein, CD278 Protein, CVID1 Protein, Ailim Protein, inducible T-cell costimulator Protein, inducible T cell co-stimulator Protein, inducible T-cell co-stimulator Protein, ICOS Protein, LOC100232284 Protein, Icos Protein
    Sujet

    Alternate Names/Synonyms: ICOS, Inducible T Cell Costimulator, CRP1, CD28-related Protein-1, AILIM

    Product Description: CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

    NCBI Accession
    NP_036224
    Pathways
    Cancer Immune Checkpoints
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