TNFRSF11A Protein (AA 30-212) (Fc Tag)
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- Antigène Voir toutes TNFRSF11A Protéines
- TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 30-212
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette TNFRSF11A protéine est marqué à la Fc Tag.
- Séquence
- AA 30-212
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 0.1 EU per μg by the LAL method.
- Top Product
- Discover our top product TNFRSF11A Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
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- Antigène
- TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))
- Autre désignation
- RANK (TNFRSF11A Produits)
- Sujet
- RANK / TNFRSF11A is a member of the tumor necrosis factor receptor family. RANK / TNFRSF11A shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Functional genomics in mice showed that RANKL (TNFSF11), a member of the TNF ligand superfamily, and RANK (TNFRSF11a), the cognate TNFR family receptor for RANKL, were essential for osteoclastogenesis in vivo. A functional interaction between RANKL, expressed by bone stromal cells of the osteoblast lineage, and RANK, expressed by osteoclast precursors of hematopoietic myeloid lineage, is necessary for osteoclast differentiation, survival, and activation.
- Poids moléculaire
- 47.2 kDa
- NCBI Accession
- NP_003830
- Pathways
- Signalisation NF-kappaB
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