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Prolactin Receptor Protein (PRLR) (AA 25-234) (Fc Tag)

PRLR Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN6253668
  • Antigène Voir toutes Prolactin Receptor (PRLR) Protéines
    Prolactin Receptor (PRLR)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 25-234
    Origine
    • 12
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 9
    • 8
    • 7
    • 6
    • 2
    • 2
    HEK-293 Cells
    Purification/Conjugué
    Cette Prolactin Receptor protéine est marqué à la Fc Tag.
    Séquence
    AA 25-234
    Attributs du produit
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.0 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product PRLR Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
  • Antigène
    Prolactin Receptor (PRLR)
    Autre désignation
    Prolactin R (PRLR Produits)
    Synonymes
    hPRLrI Protein, PRL-R Protein, prlr Protein, PRLRb Protein, PRLR Protein, tprlr Protein, DKFZp469D061 Protein, RATPRLR Protein, AI987712 Protein, Pr-1 Protein, Pr-3 Protein, Prlr-rs1 Protein, wu:fj65c07 Protein, prolactin receptor Protein, prolactin receptor L homeolog Protein, prolactin receptor S homeolog Protein, prolactin receptor a Protein, PRLR Protein, prlr.L Protein, prlr.S Protein, PR Protein, prlr Protein, Prlr Protein, prlra Protein
    Sujet
    As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
    Poids moléculaire
    51.0 kDa
    NCBI Accession
    NP_000940
    Pathways
    Signalistation JAK/STAT, Response to Growth Hormone Stimulus
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