NKIRAS1 Protein (AA 1-192) (His tag)

N° du produit ABIN6386901

Détail du produit

Antigène: NKIRAS1 (NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-192

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NKIRAS1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: NKIRAS1, 1-192aa , Human, His tag, E.coli

Pureté: > 95 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT

Stock: 4 °C

Détail du antigène

Antigène: NKIRAS1 (NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1))

Autre désignation: NKIRAS1 (NKIRAS1 Produits)

Sujet: NKIRAS1, also known as NF-kappa-B inhibitor-interacting Ras-like protein 1, belongs to the small GTPase superfamily. NKIRAS1 is atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. It may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Recombinant human NKIRAS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: NF-kappa-B inhibitor-interacting Ras-like protein 1, kappaB-Ras1, KBRAS1. NCBI no.: NP_065078

Poids moléculaire: 23.8 kDa (212aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)