BCL10 Protein (His tag)

N° du produit ABIN7279750

Détail du produit

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette BCL10 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Purification: purified by using conventional chromatography.

Pureté: > 85 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: B-cell lymphoma/leukemia 10, c-E10, CARMEN, CIPER, CLAP, mE10

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.05 M NaCl, 1 MM DTT

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Autre désignation: BCL10 (BCL10 Produits)

Synonymes: CARMEN Protein, CIPER Protein, CLAP Protein, c-E10 Protein, mE10 Protein, BCL10 Protein, AI132454 Protein, BCL-10 Protein, C81403 Protein, ME10 Protein, cE10 Protein, bcl10 Protein, B-cell CLL/lymphoma 10 Protein, B-cell lymphoma/leukemia 10-like Protein, B cell leukemia/lymphoma 10 Protein, B-cell lymphoma/leukemia 10 Protein, BCL10 Protein, Bcl10 Protein, bcl10 Protein, LOC100223183 Protein

Sujet: BCL10, also known as B-cell lymphoma/leukemia 10, contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. It is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Recombinant human BCL10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Poids moléculaire: 28.8 kDa (257aa) confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)

NCBI Accession: NP_003912

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins