RFXANK Protein (AA 1-237) (His tag)

N° du produit ABIN6387233

Détail du produit

Antigène: RFXANK (Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK))

Type de proteíne: Recombinant

Attributs du protein: AA 1-237

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RFXANK protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMELTQPA EDLIQTQQTP ASELGDPEDP GEEAADGSDT VVLSLFPCTP EPVNPEPDAS VSSPQGSSLK HSTTLTNRQR GNEVSALPAT LDCDNLVNKP DERGFTPLIW ASAFGEIETV RFLLEWGADP HILAKERESA LSLASTGGYT DIVGLLLERD VDINIYDWNG GTPLLYAVRG NHVKCVEALL ARGADLTTEA DSGYTPMDLA VALGYRKVQQ VIENHILKLF QSNLVPADPE

Pureté: > 85 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 20 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: RFXANK (Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK))

Autre désignation: RFXANK (RFXANK Produits)

Synonymes: ANKRA1 Protein, BLS Protein, F14150_1 Protein, RFX-B Protein, Tvl1 Protein, regulatory factor X associated ankyrin containing protein Protein, regulatory factor X-associated ankyrin-containing protein Protein, RFXANK Protein, Rfxank Protein

Sujet: RFXANK, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. Recombinant human RFXANK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 28 kDa (260aa), confirmed by MALDI-TOF

NCBI Accession: NP_604389

UniProt: O14593