B7h4 Protein, B7s1 Protein, B7x Protein, BC032925 Protein, B7-H4 Protein, B7H4 Protein, B7S1 Protein, B7X Protein, B7h.5 Protein, PRO1291 Protein, VCTN1 Protein, RGD1311204 Protein, V set domain containing T cell activation inhibitor 1 L homeolog Protein, V-set domain containing T cell activation inhibitor 1 Protein, V-set domain containing T-cell activation inhibitor 1 Protein, V set domain containing T cell activation inhibitor 1 Protein, vtcn1.L Protein, VTCN1 Protein, vtcn1 Protein, Vtcn1 Protein
Sujet
VTCN1, also known as v-set domain-containing T-cell activation inhibitor 1 isoform 1, is a member of the costimulatory B7 family. It has been found to be widely expressed in many kinds of tumor tissues and to play an important part in tumor progression and poor prognosis. It serves a critical role in the negative regulation of T cell-mediated antitumor immune responses. It facilitates proliferation of esophageal squamous cell carcinoma cells through promoting interleukin-6/signal transducer and activator of transcription 3 pathway activation. Recombinant human VTCN1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Poids moléculaire
26.9kDa (244aa) 28-40kDa (SDS-PAGE under reducing conditions)