PPP3R1 Protein (AA 1-170) (His tag)

N° du produit ABIN666631

Détail du produit

Antigène: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-170

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PPP3R1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: PPP3R1, 1-170aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Stock: 4 °C

Détail du antigène

Antigène: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Autre désignation: PPP3R1 (PPP3R1 Produits)

Synonymes: si:ch211-274c22.8 Protein, canb Protein, CALNB1 Protein, CNB Protein, CNB1 Protein, CaNB1 Protein, Cnb1 Protein, MCIP1 Protein, protein phosphatase 3, regulatory subunit B, alpha a Protein, protein phosphatase 3 regulatory subunit B, alpha S homeolog Protein, protein phosphatase 3 regulatory subunit B, alpha Protein, protein phosphatase 3, regulatory subunit B, alpha Protein, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Protein, ppp3r1a Protein, ppp3r1.S Protein, PPP3R1 Protein, Ppp3r1 Protein

Sujet: PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits, calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. Recombinant human PPP3R1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Protein phosphatase 3 regulatory subunit B alpha, Calcineurin subunit B type 1, CALNB1, CNB, CNB1. NCBI no.: NP_000936

Poids moléculaire: 21.5 kDa (190aa), confirmed by MALDI-TOF

Pathways: Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling