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MGMT Protein (AA 1-207) (His tag)

MGMT Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
N° du produit ABIN666723
  • Antigène Voir toutes MGMT Protéines
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-207
    Origine
    • 8
    • 2
    • 1
    • 1
    Humain
    Source
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette MGMT protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
    Attributs du produit
    MGMT, 1-207aa, Human, His-tagged, Recombinant, E.coli
    Pureté
    > 95 % by SDS - PAGE
    Top Product
    Discover our top product MGMT Protéine
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/ml (determined by Bradford assay)
    Buffer
    Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 10% glycerol
    Stock
    4 °C
  • Antigène
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    Autre désignation
    MGMT (MGMT Produits)
    Synonymes
    AGT Protein, AI267024 Protein, Agat Protein, O-6-methylguanine-DNA methyltransferase Protein, MGMT Protein, Mgmt Protein
    Sujet
    O-6-methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs O-6-methylguanine, a mutagenic DNA base damaged by endogenous and environmental alkylating agents and is involved in the cellular defense against the biological effects of O-6-methylguanine in DNA. MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. There are few reports that abnormal MGMT expression correlates with the prognosis in human solid cancers. Recombinant MGMT, fused to His-tag at N-terminus, was expressed in E.coli and was purified by conventional chromatography techniques. Synonyms: O-6-methylguanine-DNA methyltransferase, MGMT, EC 2.1.1.63, O-6-methylguanine-DNA-alkyltransferase, O-6-methylguanine-DNA methyltransferase 6 O methylguanine DNA methyltransferase, Agat, AGT, AI267024, MGC107020, Methylated DNA protein cysteine methyltransferase, Methylguanine DNA methyltransferase, O 6 methylguanine DNA alkyltransferase. NCBI no.: NP_002403
    Poids moléculaire
    23.8 kDa (227 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
    Pathways
    Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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