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STUB1 Protein (AA 1-303)

STUB1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
N° du produit ABIN666729
  • Antigène Voir toutes STUB1 Protéines
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-303
    Origine
    • 8
    • 3
    • 1
    Humain
    Source
    • 6
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    SDS-PAGE (SDS)
    Attributs du produit
    CHIP, 1-303aa, Human, Recombinant, E.coli
    Pureté
    > 90 % by SDS - PAGE
    Top Product
    Discover our top product STUB1 Protéine
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/ml (determined by Bradford assay)
    Buffer
    Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 5 mM DTT, 10% glycerol
    Stock
    4 °C
  • Antigène
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    Autre désignation
    CHIP (STUB1 Produits)
    Synonymes
    CHIP Protein, HSPABP2 Protein, NY-CO-7 Protein, SDCCAG7 Protein, UBOX1 Protein, 0610033N24Rik Protein, 2210017D18Rik Protein, 2310040B03Rik Protein, AW046544 Protein, Chip Protein, wu:fc22f04 Protein, zgc:56076 Protein, STUB1 Protein, chip Protein, ATCHIP Protein, CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN Protein, carboxyl terminus of HSC70-interacting protein Protein, STIP1 homology and U-box containing protein 1 Protein, STIP1 homology and U-Box containing protein 1 Protein, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog Protein, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Protein, STIP1 homology and U box-containing protein 1 Protein, carboxyl terminus of HSC70-interacting protein Protein, STUB1 Protein, Stub1 Protein, stub1 Protein, stub1.L Protein, LOC100282870 Protein, CHIP Protein
    Sujet
    CHIP, also known as STUB1, is a cytoplasmic protein whose amino acid sequence is highly conserved across species. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. Its interaction with these molecular chaperones results in client substrate ubiquitylation and degradation by the proteasome. Thus, CHIP acts to tilt the folding-refolding machinery toward the degradative pathway, and it serves as a link between the two. Recombinant human CHIP protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: STUB1, HSPABP2, NY-CO-7, SDCCAG7, UBOX1 , Carboxy terminus of HSP70 interacting protein Antigen NY CO 7, CLL associated antigen KW 8, Carboxy terminus of Hsp70p interacting protein, CHIP, E3 ubiquitin protein ligase CHIP, STUB 1, UBOX 1, Heat shock protein A binding protein 2 (c terminal), NY CO 7, Serologically defined colon cancer antigen 7, STIP1 homology and U Box containing protein 1. NCBI no.: NP_005852
    Poids moléculaire
    34.8 kDa (303 aa), confirmed by MALDI-TOF.
    Pathways
    Regulation of Hormone Metabolic Process, Response to Water Deprivation
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