CrkL Protein (pTry207) (His tag)

N° du produit ABIN667314

Détail du produit

Antigène: CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))

Type de proteíne: Recombinant

Attributs du protein: pTry207

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CrkL protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: CRKL, 1-303aa, Human, His tag, E.coli

Pureté: > 90 % by SDS – PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Stock: 4 °C

Détail du antigène

Antigène: CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))

Autre désignation: CRKL (CRKL Produits)

Synonymes: CRKL Protein, wu:fa55g05 Protein, wu:fj60e01 Protein, zgc:63469 Protein, 1110025F07Rik Protein, AA589403 Protein, AI325100 Protein, Crkol Protein, CRK like proto-oncogene, adaptor protein Protein, v-crk avian sarcoma virus CT10 oncogene homolog-like Protein, CRKL Protein, crkl Protein, Crkl Protein

Sujet: CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substitutete of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and has oncogenic potential. Recombinant human CRKL protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Crk-like protein,. NCBI no.: NP_005198

Poids moléculaire: 35.9 kDa (323aa), confirmed by MALDI-TOF

Pathways: Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor