ICOSLG Protein (AA 19-256) (His tag)
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- Antigène Voir toutes ICOSLG Protéines
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 19-256
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Origine
- Cynomolgus
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette ICOSLG protéine est marqué à la His tag.
- Pureté
- >90 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ICOSLG Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -20 °C
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- Antigène
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
- Autre désignation
- B7-H2 (ICOSLG Produits)
- Sujet
- ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
- Poids moléculaire
- 28.5 kDa
- NCBI Accession
- XP_005548617
- Pathways
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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