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GPC2 Protein (AA 22-556) (His tag)

GPC2 Origine: Souris Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
N° du produit ABIN6938871
  • Antigène Voir toutes GPC2 Protéines
    GPC2 (Glypican 2 (GPC2))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 22-556
    Origine
    • 5
    • 2
    • 1
    • 1
    Souris
    Source
    • 5
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette GPC2 protéine est marqué à la His tag.
    Séquence
    AA 22-556
    Pureté
    >90 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product GPC2 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
  • Antigène
    GPC2 (Glypican 2 (GPC2))
    Autre désignation
    Glypican 2 (GPC2 Produits)
    Synonymes
    2410016G05Rik Protein, glypican 2 Protein, glypican 2 (cerebroglycan) Protein, GPC2 Protein, Gpc2 Protein
    Sujet
    Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
    Poids moléculaire
    60.6 kDa
    NCBI Accession
    NP_766000
    Pathways
    Glycosaminoglycan Metabolic Process
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