Influenza Hemagglutinin HA1 Chain (HA1) (AA 19-338) protein (His tag)

N° du produit ABIN6941945

Cette protéine Recombinant est exprimée dans HEK-293 Cells.

Aperçu rapide pour Influenza Hemagglutinin HA1 Chain (HA1) (AA 19-338) protein (His tag) (ABIN6941945)

Antigène: Influenza Hemagglutinin HA1 Chain (HA1)

Type de proteíne: Recombinant

Origine: Influenza A Virus H9N2

Source: HEK-293 Cells

Pureté: >95 %

Détail du produit

Attributs du protein: AA 19-338

Purification/Conjugué: His tag

Fonction: Recombinant Influenza A [A/Guinea fowl/Hong Kong/WF10/99 (H9N2)] Hemagglutinin 1(HA1) protein produced in HEK293 cells. Protein contains a C-terminal 6x His-tag

Specificité: Recombinant Influenza A [A/Guinea fowl/Hong Kong/WF10/99 (H9N2)] Hemagglutinin 1(HA1) protein comprising amino acids 19-338, incorporating a C-terminal 6xHis tag, produced in mammalian HEK293 cells. Greater than 95% purity.

Attributs du produit: Influenza Virus Hemagglutinin 1 (HA1) (H9N2)

Information d'application

Commentaires:

This Influenza virus hemagglutinin 1 protein is derived from the HA sequence of the A/Guinea fowl/Hong Kong/WF10/99 (H9N2) strain, (Accession # Q80KD9), expressing Asp19 – Arg338, and is fused with a polyhistidine tag at the C-terminus. The total calculated MW is 37.5kDa. The influenza virus hemagglutinin protein is expressed in HEK293 cells, and DTT-reduced protein migrates as a band of 50-66kDa.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS pH 7.4

Stock: 4 °C

Stockage commentaire: 4°C

Détail du antigène

Antigène: Influenza Hemagglutinin HA1 Chain (HA1)

Autre désignation: Hemagglutinin 1 (HA1)

Sujet: Influenza, commonly known as “the flu”, is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenza virus A, Influenza virus B, and Influenza virus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease.
Influenza virus hemagglutinin (HA) is a trimer of identical subunits, each of which contains two polypeptides that result from proteolytic cleavage of a single precursor. The two polypeptides are designated HA1 and HA2. The HA2 monomer is a long helical chain, anchored into the membrane, and is “topped” by a “globule” of HA1. Cleavage of the precursor is essential for activation of membrane fusion potential and hence infectivity. For HAs of most subtypes, the site of cleavage is a single arginine residue, and cleavage occurs extracellularly by an as yet unidentified enzyme. However, some members of the H5 and H7 subtypes have acquired a series of basic residues at the cleavage site, which are recognized by an intracellular subtilisin-like enzyme. In these cases, cleavage is efficient, virus infectivity is high, and the viruses are highly pathogenic. The avian H5 influenza, which continues to spread throughout the world, excluding the Americas, is caused by such viruses. The structure of HA has been reviewed by Gamblin and Skehel in 2010.

UniProt: Q80KD9