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SIRPA Protein (Fc-His Tag)

SIRPA Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
N° du produit ABIN6961082
  • Antigène Voir toutes SIRPA Protéines
    SIRPA (Signal-Regulatory Protein alpha (SIRPA))
    Type de proteíne
    Recombinant
    Origine
    • 31
    • 19
    • 5
    • 5
    • 1
    Humain
    Source
    • 36
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette SIRPA protéine est marqué à la Fc-His Tag.
    Application
    ELISA
    Fonction
    Recombinant Human SIRPα with C-terminal human Fc and 6xHis tag
    Specificité
    SIRPα (Glu31-Tyr373) hFc (Glu99-Ala330) 6xHis tag
    Attributs du produit
    Extracellular Domain Protein
    Purification
    affinity purification
    Pureté
    The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
    Top Product
    Discover our top product SIRPA Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with deionized water
    Buffer
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Agent conservateur
    Without preservative
    Stock
    -20 °C,-80 °C
    Date de péremption
    12 months
  • Antigène
    SIRPA (Signal-Regulatory Protein alpha (SIRPA))
    Autre désignation
    SIRPalpha (SIRPA Produits)
    Synonymes
    BIT Protein, CD172A Protein, MFR Protein, MYD-1 Protein, P84 Protein, PTPNS1 Protein, SHPS1 Protein, SIRP Protein, SIRPA Protein, SIRP-A1 Protein, SIRP-B1 Protein, AI835480 Protein, Bit Protein, CD172a Protein, Ptpns1 Protein, SHP-1 Protein, SHPS-1 Protein, swc3 Protein, signal regulatory protein alpha Protein, myeloperoxidase Protein, signal-regulatory protein alpha Protein, tyrosine-protein phosphatase non-receptor type substrate 1 Protein, SIRPA Protein, MPO Protein, LOC458039 Protein, LOC100400378 Protein, LOC100590224 Protein, Sirpa Protein
    Sujet
    Synonymes: SHPS1, SIRPA, CD172A, BIT, MFR, MYD1, P84, PTPNS
    Description: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
    Poids moléculaire
    predicted molecular mass of 70-98 kDa after removal of the signal peptide.
    ID gène
    140885
    UniProt
    P78324
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