CCR5 Protein (Fc Tag)

N° du produit ABIN6964239

Détail du produit

Antigène: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CCR5 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human CCR5 Protein with C-terminal human Fc tag

Specificité: CCR5 (Met1-Ala30) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: affinity purification

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Agent conservateur: Without preservative

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Autre désignation: CCR5 (CCR5 Produits)

Synonymes: CC-CKR-5 Protein, CCCKR5 Protein, CCR-5 Protein, CD195 Protein, CKR-5 Protein, CKR5 Protein, CMKBR5 Protein, IDDM22 Protein, Ckr5 Protein, Cmkbr5 Protein, CCR1-L Protein, GPCR Protein, CCR5 Protein, AM4-7 Protein, C-C motif chemokine receptor 5 (gene/pseudogene) Protein, chemokine (C-C motif) receptor 5 Protein, C-C motif chemokine receptor 5 Protein, CCR5 Protein, Ccr5 Protein

Sujet: Synonymes: CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles, the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

Poids moléculaire: predicted molecular mass of 29.6 kDa after removal of the signal peptide.The apparent molecular mass of CCR5-hFc is 35-55 kDa due to glycosylation.

UniProt: P51681

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size