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SARS-CoV-2 Spike Protein (P.1 - gamma) (rho-1D4 tag)

Origine: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma Hôte: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE
N° du produit ABIN6964443
  • Highlights
    • Recombinant trimeric S protein of the SARS-CoV-2 variant of concern P.1.
    • Contains L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, and V1176F mutations characteristic for the SARS-CoV-2 gamma variant (P.1).
    Antigène Voir toutes SARS-CoV-2 Spike Protéines
    SARS-CoV-2 Spike
    Type de proteíne
    Recombinant
    Attributs du protein
    P.1 - gamma
    Origine
    • 223
    • 37
    • 9
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma
    Source
    • 198
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette SARS-CoV-2 Spike protéine est marqué à la rho-1D4 tag.
    Fonction
    This is the spike protein of the mutant strain P.1, also commonly known as the "Brazil mutant".
    Specificité
    Mutation that differ from canonical sequence of SPIKE protein: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176F
    Attributs du produit
    "SARS CoV-2 full-length Spike P.1 Mutation"
    All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. To help the science combat these mutants we offer the SPIKE protein of these mutants in full-length and active in its native trimeric form, stabilized with the LMNG detergent.
    Purification
    affinity chromatography
    Pureté
    > 98 % as determined by SDS-PAGE
    Top Product
    Discover our top product SARS-CoV-2 Spike Protéine
  • Commentaires

    Further modifications:
    - furin cleavage site "682-RRAR|SV-687" mutated to "682-GSAG|PP-687"
    - C-terminal Rho1D4 tag fused with spacer "GSSG" to protein sequence
    Size: 1286 amino acids (including Rho1D4 tag and linker)

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    20 mM Hepes pH 7.5, 150 mM NaCl, 0.001 % LMNG
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Avoid freeze-thaw cycles
  • Erickson, Logsdon, Rhea, Hansen, Holden, Banks, Smith, German, Farr, Morley, Weaver, Hirsch, Kovac, Kontsekova, Baumann, Omer, Raber: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." dans: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).

    Bhalla, Payam, Morelli, Sharma, Johnson, Thomson, Jolly, Canfarotta: "Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum." dans: Sensors and actuators. B, Chemical, Vol. 365, pp. 131906, (2022) (PubMed).

  • Antigène
    SARS-CoV-2 Spike
    Autre désignation
    SARS2 Spike glycoprotein (SARS-CoV-2 Spike Produits)
    Synonymes
    E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein
    Classe de substances
    Viral Protein
    Poids moléculaire
    142114 Da
    UniProt
    P0DTC2
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