Cette SARS-CoV-2 Nucleocapsid protéine est marqué à la His tag.
Fonction
SARS-CoV-2 Nucleocapsid protein (D3L, S235F), His Tag
Séquence
AA 1-419
Attributs du produit
SARS-CoV-2 Nucleocapsid protein (D3L, S235F), His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (D3L, S235F) (Accession # QHO62115.1(D3L, S235F). D3L/ S235F were identified in the SARS-CoV-2 variant (known as 20B/501Y.V1, VOC 202012/01, or B.1.1.7 lineage) which emerged in the United Kindom.
Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology, 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.