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CD8 alpha Protein (AA 22-182) (His tag)

CD8A Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN7013444
  • Antigène Voir toutes CD8 alpha (CD8A) Protéines
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 22-182
    Origine
    • 15
    • 10
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain
    Source
    • 14
    • 7
    • 5
    • 5
    • 3
    HEK-293 Cells
    Purification/Conjugué
    Cette CD8 alpha protéine est marqué à la His tag.
    Attributs du produit
    Human CD8 alpha / CD8A Protein, His Tag
    Pureté
    >95 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD8A Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Stock
    -20 °C
  • Antigène
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Autre désignation
    CD8 alpha (CD8A Produits)
    Synonymes
    cd8 Protein, LOC100136450 Protein, BB154331 Protein, Ly-2 Protein, Ly-35 Protein, Ly-B Protein, Lyt-2 Protein, zgc:136643 Protein, CD8 Protein, Leu2 Protein, MAL Protein, p32 Protein, RHACD8-4 Protein, CD8a molecule Protein, uncharacterized LOC100125537 Protein, CD8 alpha Protein, CD8 antigen, alpha chain Protein, T-cell surface glycoprotein CD8 alpha chain Protein, Cd8a Protein, LOC100125537 Protein, LOC100136450 Protein, CD8A Protein, cd8a Protein, LOC100126556 Protein
    Sujet
    Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
    Poids moléculaire
    19.5 kDa
    NCBI Accession
    NP_001759
    Pathways
    TCR Signaling
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