Tissue factor Protein (AA 33-251) (His tag)

N° du produit ABIN7013638

Détail du produit

Antigène: Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 33-251

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Tissue factor protéine est marqué à la His tag.

Attributs du produit: Human Coagulation Factor III / Tissue Factor Protein, His Tag (MALS verified)

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: MALS verified

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Stock: -20 °C

Détail du antigène

Antigène: Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))

Autre désignation: Coagulation Factor III (F3 Produits)

Synonymes: CD142 Protein, TF Protein, TFA Protein, PRO1557 Protein, PRO2086 Protein, TFQTL1 Protein, f3 Protein, AA409063 Protein, Cf-3 Protein, Cf3 Protein, tf Protein, zgc:112151 Protein, coagulation factor III, tissue factor Protein, transferrin Protein, coagulation factor IIIa Protein, coagulation factor III Protein, tissue factor Protein, coagulation factor IIIb Protein, coagulation factor III (thromboplastin, tissue factor) S homeolog Protein, F3 Protein, TF Protein, f3a Protein, tf Protein, f3b Protein, f3.S Protein

Sujet: Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.

Poids moléculaire: 26.7 kDa

NCBI Accession: NP_001984

Pathways: Positive Regulation of Endopeptidase Activity, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling