CD99L2 Protein (His tag)

N° du produit ABIN7320248

Détail du produit

Antigène: CD99L2 (CD99 Molecule-Like 2 (CD99L2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette CD99L2 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CD99L2 Protein (His Tag)(Active)

Séquence: Met 1-Ala 164

Attributs du produit: A DNA sequence encoding the mouse CD99L2 (NP_612182.1) extracellular domain (Met 1-Ala 164) was expressed, fused with a polyhistidine tag at the C-terminus.

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind biotinylated recombinant mouse CD99L2 in functional ELISA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD99L2 (CD99 Molecule-Like 2 (CD99L2))

Autre désignation: CD99L2 (CD99L2 Produits)

Synonymes: AW548191 Protein, Mic2l1 Protein, Xap89 Protein, CD99B Protein, MIC2L1 Protein, vms-tm2 Protein, CD99 antigen-like 2 Protein, CD99 molecule like 2 Protein, CD99 molecule-like 2 Protein, Cd99l2 Protein, CD99L2 Protein

Sujet:

Background: CD99 antigen-like protein 2, also known as MIC2-like protein 1, CD99L2 and MIC2L1, is a single-pass type I  membrane protein which belongs to the CD99 family. CD99L2 is expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle, ovary, thymus, testis and uterus. Lower expression of CD99L2 is seen in thymus. It is also expressed in E18 uterus and placenta. CD99 and CD99L2 were required for leukocyte extravasation in the cremaster after stimulation with tumor necrosis factor-alpha, where the need for PECAM-1 is known to be bypassed. CD99 and CD99L2 act independently of PECAM-1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane. CD99L2 may function as a homophilic adhesion molecule. It functions in leukocyte-endothelial cell interactions during leukocyte extravasation, and in particular, at the diapedesis step. CD99L2 does not seem to be involved in docking of leukocytes to the vessel wall or in lymphocyte diapedesis.

Synonym: AW548191;Mic2l1;Xap89

Poids moléculaire: 16.3 kDa

NCBI Accession: NP_612182