COL18A1 Protein (His tag)
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- Antigène Voir toutes COL18A1 Protéines
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- Type de proteíne
- Recombinant
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Origine
- Souris
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Source
- Human Cells
- Purification/Conjugué
- Cette COL18A1 protéine est marqué à la His tag.
- Fonction
- Recombinant Mouse COL18A1/Endostatin Protein (His Tag)
- Séquence
- His1591-Lys1774
- Attributs du produit
- Recombinant Mouse Collagen alpha-1(XVIII) chain is produced by our Mammalian expression system and the target gene encoding His1591-Lys1774 is expressed with a 6His tag at the C-terminus.
- Pureté
- > 90 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- Autre désignation
- COL18A1/Endostatin (COL18A1 Produits)
- Synonymes
- KNO Protein, KNO1 Protein, KS Protein, cb371 Protein, cb529 Protein, fc96d06 Protein, sb:cb529 Protein, wu:fb47h10 Protein, wu:fb77g12 Protein, wu:fc50f04 Protein, wu:fc96d06 Protein, wu:fk02h12 Protein, kno Protein, kno1 Protein, collagen type XVIII alpha 1 chain Protein, collagen type XVIII alpha 1 chain a Protein, collagen, type XVIII, alpha 1 Protein, collagen type XVIII alpha 1 Protein, COL18A1 Protein, col18a1a Protein, Col18a1 Protein, col18a1 Protein
- Classe de substances
- Chemical
- Sujet
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Background: Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9, and cathepsins S, B and L. The N-terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96 % aa sequence identity with rat and 85-87 % with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration. Endostatin may also be involved with down-regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.
Synonym: antiangiogenic agent,COL18A1,collagen alpha-1(XVIII)chain, collagen,type XVIII,Endostatin
- Poids moléculaire
- 21.2 kDa
- UniProt
- P39061
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