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COL18A1 Protein (His tag)

COL18A1 Origine: Souris Hôte: Human Cells Recombinant > 90 % as determined by SDS-PAGE
N° du produit ABIN7320492
  • Antigène Voir toutes COL18A1 Protéines
    COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
    Type de proteíne
    Recombinant
    Origine
    • 7
    • 3
    • 2
    Souris
    Source
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    Human Cells
    Purification/Conjugué
    Cette COL18A1 protéine est marqué à la His tag.
    Fonction
    Recombinant Mouse COL18A1/Endostatin Protein (His Tag)
    Séquence
    His1591-Lys1774
    Attributs du produit
    Recombinant Mouse Collagen alpha-1(XVIII) chain is produced by our Mammalian expression system and the target gene encoding His1591-Lys1774 is expressed with a 6His tag at the C-terminus.
    Pureté
    > 90 % as determined by SDS-PAGE
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
    Autre désignation
    COL18A1/Endostatin (COL18A1 Produits)
    Synonymes
    KNO Protein, KNO1 Protein, KS Protein, cb371 Protein, cb529 Protein, fc96d06 Protein, sb:cb529 Protein, wu:fb47h10 Protein, wu:fb77g12 Protein, wu:fc50f04 Protein, wu:fc96d06 Protein, wu:fk02h12 Protein, kno Protein, kno1 Protein, collagen type XVIII alpha 1 chain Protein, collagen type XVIII alpha 1 chain a Protein, collagen, type XVIII, alpha 1 Protein, collagen type XVIII alpha 1 Protein, COL18A1 Protein, col18a1a Protein, Col18a1 Protein, col18a1 Protein
    Classe de substances
    Chemical
    Sujet

    Background: Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9, and cathepsins S, B and L. The N-terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96 % aa sequence identity with rat and 85-87 % with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration. Endostatin may also be involved with down-regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.

    Synonym: antiangiogenic agent,COL18A1,collagen alpha-1(XVIII)chain, collagen,type XVIII,Endostatin

    Poids moléculaire
    21.2 kDa
    UniProt
    P39061
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