CD11b Protein (His tag)

N° du produit ABIN7319924

Détail du produit

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette CD11b protéine est marqué à la His tag.

Fonction: Recombinant Human ITGAM/CD11b (C-6His)

Séquence: Phe17-Asn1105

Attributs du produit: Recombinant Human Integrin Alpha-M is produced by our Mammalian expression system and the target gene encoding Phe17-Asn1105 is expressed with a 6His tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation: ITGAM/CD11b (ITGAM Produits)

Synonymes: CD11b/CD18 Protein, CR3 Protein, CR3A Protein, Cd11b Protein, F730045J24Rik Protein, Ly-40 Protein, MAC1 Protein, Mac-1 Protein, Mac-1a Protein, CD11B Protein, MAC-1 Protein, MAC1A Protein, MO1A Protein, SLEB6 Protein, C3bi Protein, integrin subunit alpha M Protein, integrin alpha M Protein, integrin, alpha M (complement component 3 receptor 3 subunit) Protein, integrin alpha-M Protein, ITGAM Protein, Itgam Protein, LOC100351865 Protein

Sujet:

Background: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens . It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain, regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.

Synonym: Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A

Poids moléculaire: 121.4 kDa

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation