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PRSS8 Protein (AA 30-289) (His tag)

PRSS8 Origine: Souris Hôte: Baculovirus infected Insect Cells Recombinant > 97 % as determined by SDS-PAGE
N° du produit ABIN7197548
  • Antigène Voir toutes PRSS8 Protéines
    PRSS8 (Protease, serine, 8 (PRSS8))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 30-289
    Origine
    • 6
    • 3
    • 2
    Souris
    Source
    • 4
    • 4
    • 2
    • 1
    Baculovirus infected Insect Cells
    Purification/Conjugué
    Cette PRSS8 protéine est marqué à la His tag.
    Fonction
    Recombinant Mouse Prostasin/PRSS8 Protein (aa 30-289, His Tag)
    Séquence
    Ala 30-Gln 289
    Attributs du produit
    A DNA sequence encoding the mouse PRSS8 (EDL17608.1 ) (Ala 30-Gln 289) was expressed,fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
    Pureté
    > 97 % as determined by SDS-PAGE
    niveau d'endotoxine
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product PRSS8 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    PRSS8 (Protease, serine, 8 (PRSS8))
    Autre désignation
    Prostasin/PRSS8 (PRSS8 Produits)
    Synonymes
    CAP1 Protein, PROSTASIN Protein, prostasin Protein, 2410039E18Rik Protein, AI313909 Protein, C79772 Protein, fr Protein, mCAP1 Protein, protease, serine 8 Protein, protease, serine, 8 Protein, protease, serine 8 (prostasin) Protein, PRSS8 Protein, Prss8 Protein
    Sujet

    Background: Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.

    Synonym: 2410039E18Rik,AI313909,C79772,CAP1,fr,mCAP1

    Poids moléculaire
    29.3 kDa
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