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PTPN2 Protein (AA 2-314) (His tag)

PTPN2 Origine: Souris Hôte: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
N° du produit ABIN7197593
  • Antigène Voir toutes PTPN2 Protéines
    PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 2-314
    Origine
    • 7
    • 2
    • 1
    Souris
    Source
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Baculovirus infected Insect Cells
    Purification/Conjugué
    Cette PTPN2 protéine est marqué à la His tag.
    Fonction
    Recombinant Mouse PTPN2/PTPT Protein (aa 2-314, His Tag)(Active)
    Séquence
    Ser 2-Asn 314
    Attributs du produit
    A DNA sequence encoding the mouse PTPN2 (Q06180-1) (Ser 2-Asn 314) was fused with a polyhistidine tag at the N-terminus.
    Pureté
    > 90 % as determined by SDS-PAGE
    niveau d'endotoxine
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Biological Activity Comment
    Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 15 nmoles/min/μg.
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    Discover our top product PTPN2 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 20 % glycerol, 0.1 mM TCEP
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
    Autre désignation
    PTPN2/PTPT (PTPN2 Produits)
    Synonymes
    PTN2 Protein, PTPT Protein, TC-PTP Protein, TCELLPTP Protein, TCPTP Protein, AI325124 Protein, Ptpt Protein, PTP-1B Protein, cb806 Protein, ptpn2 Protein, ptpn2l Protein, wu:fc10h07 Protein, zgc:55339 Protein, zgc:76973 Protein, hm:zeh1546 Protein, zgc:63623 Protein, ptn2 Protein, ptpt Protein, tc-ptp Protein, tcellptp Protein, tcptp Protein, protein tyrosine phosphatase, non-receptor type 2 Protein, protein tyrosine phosphatase, non-receptor type 2 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 2, b Protein, protein tyrosine phosphatase, non-receptor type 2, a Protein, protein tyrosine phosphatase, non-receptor type 2 L homeolog Protein, PTPN2 Protein, Ptpn2 Protein, ptpn2.S Protein, ptpn2b Protein, ptpn2a Protein, ptpn2.L Protein
    Sujet

    Background: Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

    Synonym: AI325124;Ptpt;TC-PTP

    Poids moléculaire
    38.7 kDa
    Pathways
    EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
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