Vitamin D Receptor Protein (VDR) (His tag)

N° du produit ABIN7320044

Détail du produit

Antigène: Vitamin D Receptor (VDR)

Type de proteíne: Recombinant

Origine: Souris

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette Vitamin D Receptor protéine est marqué à la His tag.

Fonction: Recombinant Mouse VDR/NR1I1 Protein (His Tag)

Séquence: Met1-Ser422

Attributs du produit: A DNA sequence encoding the mouse VDR (P48281) (Met1-Ser422) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 86 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Vitamin D Receptor (VDR)

Autre désignation: VDR/NR1I1 (VDR Produits)

Synonymes: vdrbeta Protein, vdr0 Protein, LOC100136219 Protein, NR1I1-B Protein, gb:dq017633 Protein, vdr-b Protein, Ci-VDR-b Protein, VDR Protein, LOC100221284 Protein, vdr-A Protein, xVDR Protein, Nr1i1 Protein, vdr Protein, NR1I1 Protein, PPP1R163 Protein, vitamin D (1,25- dihydroxyvitamin D3) receptor Protein, vitamin D receptor Protein, vitamin D3 receptor A Protein, vitamin D receptor b Protein, nuclear receptor VDR-b Protein, vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog Protein, vitamin D (1,25-dihydroxyvitamin D3) receptor Protein, vitamin D receptor a Protein, vdr Protein, vdr0 Protein, VDR Protein, LOC100136219 Protein, vdrb Protein, vdr-b Protein, vdr.L Protein, Vdr Protein, vdra Protein

Classe de substances: Chemical

Sujet:

Background: VDR (vitamin D(1,25- dihydroxyvitamin D3)receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor family. VDRs repress expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. VDR is expressed in the intestine, thyroid and kidney and has a vital role in calcium homeostasis. It is the nuclear hormone receptor, also called transcription factor that mediates the action of vitamin D3. Inherited mutations in the VDR gene leads to rickets.

Synonym: Nr1i1

Poids moléculaire: 49.2 kDa

UniProt: P48281

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway