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ErbB2/Her2 Protein (AA 23-652) (His tag)

ErbB2/Her2 Origine: Cynomolgus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274794
  • Antigène Voir toutes ErbB2/Her2 Protéines
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 23-652
    Origine
    • 45
    • 9
    • 7
    • 1
    • 1
    Cynomolgus
    Source
    • 37
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette ErbB2/Her2 protéine est marqué à la His tag.
    Fonction
    Cynomolgus Her2/ErbB2 Protein
    Séquence
    Thr23-Thr652
    Attributs du produit
    Recombinant Cynomolgus Her2/ErbB2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr23-Thr652.
    Pureté
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Cynomolgus Her2, His Tag at 0.2μg/ml (100μl/Well) on the plate. Dose response curve for Anti-Her2 Antibody, hFc Tag with the EC50 of 13.8ng/ml determined by ELISA. See testing image for detail.
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    Discover our top product ErbB2/Her2 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Autre désignation
    Her2 (ErbB2/Her2 Produits)
    Synonymes
    CD340 Protein, HER-2 Protein, HER-2/neu Protein, HER2 Protein, MLN 19 Protein, NEU Protein, NGL Protein, TKR1 Protein, Erbb-2 Protein, Neu Protein, c-erbB2 Protein, c-neu Protein, mKIAA3023 Protein, wu:fv70f10 Protein, zgc:63601 Protein, erb2 Protein, erb-b2 receptor tyrosine kinase 2 Protein, ERBB2 Protein, Erbb2 Protein, erbb2 Protein
    Sujet
    ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.
    Poids moléculaire
    70.4 kDa. Due to glycosylation, the protein migrates to 85-105 kDa based on Tris-Bis PAGE result.
    NCBI Accession
    XP_005584091
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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