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Prolactin Receptor Protein (PRLR) (AA 25-234) (His tag)

PRLR Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7275468
  • Antigène Voir toutes Prolactin Receptor (PRLR) Protéines
    Prolactin Receptor (PRLR)
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 25-234
    Origine
    • 12
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 9
    • 8
    • 7
    • 6
    • 2
    • 2
    HEK-293 Cells
    Purification/Conjugué
    Cette Prolactin Receptor protéine est marqué à la His tag.
    Fonction
    Human PRLR Protein
    Séquence
    Gln25-Asp234
    Attributs du produit
    Recombinant Human PRLR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln25-Asp234.
    Pureté
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Human PRLR, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 78.7ng/ml determined by ELISA. The affinity constant of 0.96nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in 50 mM Tris, 150nM Nacl ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Prolactin Receptor (PRLR)
    Autre désignation
    PRLR (PRLR Produits)
    Synonymes
    hPRLrI Protein, PRL-R Protein, prlr Protein, PRLRb Protein, PRLR Protein, tprlr Protein, DKFZp469D061 Protein, RATPRLR Protein, AI987712 Protein, Pr-1 Protein, Pr-3 Protein, Prlr-rs1 Protein, wu:fj65c07 Protein, prolactin receptor Protein, prolactin receptor L homeolog Protein, prolactin receptor S homeolog Protein, prolactin receptor a Protein, PRLR Protein, prlr.L Protein, prlr.S Protein, PR Protein, prlr Protein, Prlr Protein, prlra Protein
    Sujet
    Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers.
    Poids moléculaire
    25.5 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Tris-Bis PAGE result.
    Pathways
    Signalistation JAK/STAT, Response to Growth Hormone Stimulus
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