PLVAP Protein (AA 49-442) (His tag)
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- Antigène Voir toutes PLVAP Protéines
- PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 49-442
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PLVAP protéine est marqué à la His tag.
- Fonction
- Human PLVAP Protein
- Séquence
- Tyr49-Gly442
- Attributs du produit
- Recombinant Human PLVAP Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Tyr49-Gly442.
- Pureté
- > 95 % as determined by Tris-Bis PAGE
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS, 200 mM L-arginine ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
- Autre désignation
- PLVAP (PLVAP Produits)
- Synonymes
- MECA32 Protein, Pv1 Protein, FELS Protein, PV-1 Protein, PV1 Protein, gp68 Protein, plasmalemma vesicle associated protein Protein, Plvap Protein, PLVAP Protein
- Sujet
- Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier, however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases.
- Poids moléculaire
- 45.97 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
- UniProt
- Q9BX97
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